Front Endocrinol (Lausanne) . 2025 Aug 4;16:1602727. doi: 10.3389/fendo.2025.1602727 Kai Huang 1,* , Haili Cai 2 Author information Article notes Copyright and License information PMCID: PMC12358290 PMID: 40831953 https://pmc.ncbi.nlm.nih.gov/articles/PMC12358290/ Abstract: Osteoarthritis (OA) is a degenerative joint disease that causes pain, stiffness, and reduced mobility, significantly affecting the quality of life for millions globally. Current treatments focus on symp